Nexum Capsules 40Mg (1 Strip = 7 Capsules)

Description

Requires Prescription: Yes

Generics: Esomeprazole

Used For: Acidity & Ulcers

How It Works: Esomeprazole inhibits the proton pump by irreversibly binding to the H+/K+ ATPase enzyme in the stomach’s parietal cells. This action reduces the secretion of hydrochloric acid, thereby decreasing stomach acidity and altering gastric pH.

Usage and Safety:

Dosage: As prescribed by your healthcare provider.

Side Effects: Common side effects include headache, gastrointestinal upset, skin reactions, and dry mouth. Rare side effects may include angioedema, anaphylaxis, and fundic gland polyps.

Drug Interactions: May interact with phenytoin, warfarin, clopidogrel, ketoconazole, itraconazole, voriconazole, diazepam, citalopram, imipramine, clomipramine, CYP3A4 inhibitors or inducers, tacrolimus, digoxin, erlotinib, and methotrexate.

Indication: Used for the treatment of heartburn, gastroesophageal reflux disease (GERD), gastritis, and ulcers.

When Not to Use: Contraindicated in individuals with known hypersensitivity to proton pump inhibitors (PPIs). Hypersensitivity reactions such as angioedema, anaphylaxis, bronchospasm, acute interstitial nephritis, and urticaria have been reported.

Precautions:

Long-Term Use: Extended daily use (e.g., longer than 3 years) may lead to malabsorption or a deficiency of vitamin B12 (cyanocobalamin).

Warnings:

Hypomagnesemia: Rarely, prolonged PPI use can lead to low magnesium levels (hypomagnesemia).

Fracture Risk: Long-term and high-dose PPI therapy may increase the risk of osteoporosis-related fractures in the hip, wrist, or spine

Clopidogrel Interaction: Avoid concurrent use with clopidogrel due to potential interactions.

Additional Information

Pregnancy Category: Consult your physician before using this medication if you are pregnant or planning to become pregnant.

Storage: Store at room temperature, away from direct light and heat.